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Agile Bioscience is proud to announce a major expansion of our analytical toolkit – the integration of Wyatt Technology's miniDAWN TREOS MALS detector and Optilab t-REX RI detector. This state-of-the-art setup offers exceptional advantages for advanced characterization of macromolecules and complex mixtures.
What is SEC-MALS?
SEC-MALS stands for Size Exclusion Chromatography coupled with Multi-Angle Light Scattering and Refractive Index detectors. This powerful technique offers:
Absolute Molecular Weight: Determines weight without relying on column calibration or reference standards.
Size Analysis: Measures gyration radius (Rg), providing insight into macromolecular size and conformation.
Conjugate Analysis: Ideal for characterizing protein-conjugates, such as those used in biotherapeutics.
Aggregation Studies: Sensitive detection and characterization of aggregates in biomolecular samples.
Why Wyatt miniDAWN TREOS and Optilab t-REX?
We chose these top-tier Wyatt detectors for the following reasons:
miniDAWN TREOS: This MALS detector offers industry-leading sensitivity and precision across a wide molecular weight range.
Optilab t-REX: This differential refractive index detector provides ultra-sensitive concentration measurement and extended dynamic range.
Integrated Workflow: Seamless integration with existing chromatography systems for streamlined analysis.
Key Applications for Agile Bioscience
This chromatographic instrumentation upgrade supercharges our capabilities in several critical areas:
Biopharmaceutical Development: Comprehensive analysis of biotherapeutics, including size, aggregation state, and conjugation ratios.
Polymer Characterization: Detailed understanding of polymer molecular weight distributions, branching, and structural properties.
Nanoparticles: Characterization of size, weight, and aggregation state of nanoparticles for materials research and drug delivery applications.
Complex Mixtures: Precise analysis of complex samples in food science, environmental studies, and more.
The Benefits for Agile Bioscience
By incorporating the Wyatt miniDAWN TREOS and Optilab t-REX, we provide our clients with:
Unmatched Accuracy: Absolute molecular weight measurements independent of reference standards.
Detailed Insights: In-depth information about macromolecule size, structure, and interactions.
Robust and Reproducible Characterization: Minimized uncertainty for confident decision-making.
Expanded Analytical Scope: Tackle challenging, complex samples across diverse industries.
The Agile Bioscience Advantage
We believe providing cutting-edge analytical tools is a cornerstone of delivering exceptional research services. Our dedication to staying ahead of the curve helps us drive innovation for our customers, pushing the boundaries of scientific discovery.
If you're looking for a partner with the technology and expertise to deliver thorough macromolecule characterization, contact us to discuss how we can help!
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