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Agile Bioscience understands that protein structure is inextricably linked to function. That's why we've equipped our lab with the powerful Jasco J-1500 Circular Dichroism (CD) Spectrophotometer – a key tool for in-depth biophysical characterization.
What is Circular Dichroism?
CD spectroscopy analyzes the differential absorption of left- and right-circularly polarized light by chiral molecules like proteins. This technique reveals crucial information about:
Secondary Structure: The proportion of alpha-helices, beta-sheets, and other structural elements within a protein.
Tertiary Structure: Overall 3D folding of the protein and how it changes in response to different conditions.
Stability & Aggregation: Monitoring protein stability, denaturation, and potential aggregation propensity.
Jasco J-1500: Standout Features
The J-1500 sets the standard for CD spectroscopy with features that make it perfect for our research needs:
Extended Wavelength Range: Allows for measurement in both the far-UV and near-UV spectral regions for enhanced data collection.
Exceptional Sensitivity: Accurately analyzes even dilute protein samples with high signal-to-noise ratio.
Temperature Control: Facilitates thermal stability and melting studies to determine critical thermodynamic parameters.
Multiple Sampling Accessories: Provides the flexibility to analyze various sample types, including liquids, films, and solids.
Applications for Biophysical Characterization
The J-1500 empowers us in projects such as:
Biopharmaceutical Development: Characterization of therapeutic proteins and antibodies, ensuring their structural integrity, stability, and comparability across batches.
Structural Biology: Elucidating the structure-function relationships of novel proteins and enzymes.
Biomaterials: Evaluating the secondary structure of biomimetic peptides and materials for tissue engineering.
Drug Binding Studies: Examining conformational changes upon ligand interactions, helping understand drug mechanism of action.
The Agile Bioscience Difference
Our investment in the Jasco J-1500 demonstrates our dedication to providing the most comprehensive biophysical characterization services. Beyond just collecting data, our experts interpret CD spectra with precision, delivering actionable insights to support your research goals.
Partner with Us
If you need to probe the structure and stability of proteins or other biomolecules, look no further than Agile Bioscience. The Jasco J-1500, coupled with our team's expertise, can illuminate the critical details necessary for project success.
Contact us today to see how our CD spectroscopy services can make a difference!
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