Agile BioScience: Deciphering Protein Structure with Circular Dichroism
Circular Dichroism (CD) spectroscopy is a sensitive technique for analyzing protein secondary and tertiary structure. Agile BioScience leverages CD to reveal crucial insights into your biopharmaceutical’s conformation, stability, and potential changes.
Why CD Matters:
- Secondary Structure Analysis (Far-UV): CD detects characteristic patterns of alpha-helices, beta-sheets, and other structural elements, providing insights into protein folding and function.
- Tertiary Structure Analysis (Near-UV) reveal the distribution of amino acid residues with chromophoric side chains, including tryptophan, phenylalanine, tyrosine, and variations in the disulfide bond environment.
- Detects Subtle Changes: Highly sensitive to even minor structural alterations, aiding in the assessment of stability, manufacturing variations, and potential degradation pathways.
Our Approach:
- Far-UV and Near-UV Expertise: We perform CD analysis across the relevant spectral ranges for comprehensive structural characterization.
- Precise Instrumentation: Our CD spectrometers provide accurate, reproducible measurements.
- Expert Data Interpretation: Our team analyzes CD spectra to identify secondary and tertiary structure elements and pinpoint potential structural changes.
Benefits of Choosing Agile BioScience:
- In-Depth Structural Understanding: Gain detailed knowledge of your protein’s conformation.
- Stability Assessment: Monitor structural integrity in response to environmental factors, formulation changes, or process modifications.
- Problem-Solving Support: Identify potential root causes of stability issues.
Contact us to discover how CD analysis can accelerate your biopharmaceutical development.
Characterization
- Dynamic Light Scattering (DLS)
- Micro Flow Imaging (MFI)
- Liquid Chromatography
- SEC-MALS
- SV-AUC
- Fourier-Transform Infrared (FTIR)
- Differential Scanning Calorimetry (DSC)
- Secondary, Tertiary and Higher Order Protein Structure
- CE-SDS
- Image Based Capillary Electrophoresis
- Intact Molecular Weight Analysis
- Oligosaccharide Profiling Services
- Disulfide Bond Mapping Services
- N- and O-linked glycosylation services
- Peptide Mapping Services
- C-terminal Sequencing
- N-Terminal Sequencing
- Amino Acid Analysis
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