Agile BioScience: Probing Protein Stability with DSC
Differential Scanning Calorimetry (DSC) is a powerful technique for understanding the thermal stability and unfolding behavior of biopharmaceuticals. Agile BioScience employs DSC to support your development process, ensuring optimal product quality and efficacy.
Why DSC Matters:
- Reveals Unfolding Transitions: DSC measures the heat absorbed or released during protein unfolding, providing insights into conformational stability.
- Determines Melting Temperature (Tm): Identifies the temperature at which a protein begins to denature, a critical parameter for storage and formulation.
- Assesses Manufacturing Impact: Compares batches and investigates how process changes might affect protein stability.
- Supports Regulatory Submissions: Provides data relevant to product quality and stability assessments.
Our Approach:
- High-Sensitivity Instrumentation: Our DSC systems deliver accurate and precise measurements of thermal transitions.
- Tailored Method Development: We carefully optimize experimental conditions to match your specific biopharmaceutical.
- Expert Data Interpretation: Our team translates DSC data into actionable insights about your protein’s stability profile.
Benefits of Choosing Agile BioScience:
- Confidence in Stability: Gain a deep understanding of your protein’s thermal behavior.
- Formulation Optimization: Identify conditions that maximize stability and shelf-life.
- Data-Driven Decision Making: Make informed decisions about manufacturing, storage, and product development.
Contact us to learn how DSC can ensure the stability and quality of your biopharmaceuticals.
Characterization
- Dynamic Light Scattering (DLS)
- Micro Flow Imaging (MFI)
- Liquid Chromatography
- Circular Dichroism (CD)
- SEC-MALS
- SV-AUC
- Fourier-Transform Infrared (FTIR)
- Secondary, Tertiary and Higher Order Protein Structure
- CE-SDS
- Image Based Capillary Electrophoresis
- Intact Molecular Weight Analysis
- Oligosaccharide Profiling Services
- Disulfide Bond Mapping Services
- N- and O-linked glycosylation services
- Peptide Mapping Services
- C-terminal Sequencing
- N-Terminal Sequencing
- Amino Acid Analysis
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