Dynamic Light Scattering (DLS) Characterization with Aunty
At Agile Bioscience, we leverage the power of Aunty – the fastest and highest-throughput protein stability characterization platform – to deliver cutting-edge Dynamic Light Scattering (DLS) analysis.
What is DLS?
Dynamic Light Scattering (DLS) is a gold-standard biophysical technique for determining the hydrodynamic size, size distribution, and polydispersity index (PDI) of proteins, peptides, nanoparticles, and biologics in solution. By measuring the fluctuations in scattered light due to Brownian motion, DLS provides deep insights into:
- Protein aggregation and oligomerization
- Sample homogeneity and stability
- Formulation screening under stress conditions
- Batch-to-batch comparability and sameness assessment
Why Aunty for DLS?
Unlike conventional instruments, Aunty integrates fluorescence, static light scattering (SLS), and DLS in a high-throughput 96-well format. This enables rapid thermal melting and aggregation analysis with unmatched precision and speed.
Key advantages of Aunty DLS characterization:
- Ultra-fast analysis: Entire 96-well plate scanned in minutes.
- High sensitivity: Detects subtle changes in particle size and aggregation onset.
- Multiparametric output: Simultaneous readouts for fluorescence, SLS, and DLS.
- Formulation development support: Screen multiple excipients, buffers, and stress conditions in parallel.
- Biopharma ready: Ideal for monoclonal antibodies, biosimilars, peptides, oligonucleotides, and nanoparticles.
Applications at Agile Bioscience
With DLS characterization on Aunty, we provide tailored solutions across R&D and regulatory needs:
- Protein aggregation profiling (early vs. late-stage aggregation)
- Thermal stability studies for biologics and peptides
- Formulation screening for enhanced shelf-life and reduced aggregation
- Comparative characterization for biosimilars and generic biologics
- Nanoparticle size analysis for advanced drug delivery systems
Why Partner with Agile Bioscience?
Our DLS expertise with Aunty ensures that you receive high-resolution, reproducible, and regulatory-compliant data. We combine advanced instrumentation with scientific insight to accelerate biologics development and ensure product quality.
Characterization
- Micro Flow Imaging (MFI)
- Liquid Chromatography
- Circular Dichroism (CD)
- SEC-MALS
- SV-AUC
- Fourier-Transform Infrared (FTIR)
- Differential Scanning Calorimetry (DSC)
- Secondary, Tertiary and Higher Order Protein Structure
- CE-SDS
- Image Based Capillary Electrophoresis
- Intact Molecular Weight Analysis
- Oligosaccharide Profiling Services
- Disulfide Bond Mapping Services
- N- and O-linked glycosylation services
- Peptide Mapping Services
- C-terminal Sequencing
- N-Terminal Sequencing
- Amino Acid Analysis
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